A match in the second round of the quarter-finals of the 2020/21 UEFA Cup was played at the Olympic Stadium in Rome. Rome played at home against the Dutch giants Ajax. The Red Wolves had a 2-1 away win in the first round. Ajax's promotion is in sight. After the whole game, the two sides reached a tie with 1-1, but Roma finally succeeded in the semi-finals of the Europa League with Manchester United with a total score of 3-2.

At the beginning of the first half, Roma, who played at home, took the lead. In the 4th minute of the game, Pellegrini rushed into the penalty area with the ball and deducted Klebe's low shot. The ball was easily confiscated by goalkeeper Steklunberg because the angle of the shot was too right. In the 8th minute, Calafioli knocked the ball across the top of the arc at the front of the penalty area, and Dzeko kept the ball straight and sent a through ball. Velitu quickly advanced to the center of the penalty area and succeeded. However, the referee immediately whistled that Wellertu was offside and the goal was declared invalid.

After the first blow was unsuccessful, Roma immediately devoted more energy to the defensive end, and Ajax also seized the opportunity to organize several effective offenses. In the 9th minute, Tadic made a pass from the right corner, and Tagliafico headed the goalkeeper in the center of the penalty area. In the 12th minute, Rome goalkeeper Paul Lopez made a mistake when passing the ball, and the ball was directly intercepted by Anthony; the latter broke into the bottom right of the penalty area with the ball and then grabbed the ball back to the triangle before P Lopez made a save. Sen Zhonglu followed up to face the empty goal, but the ball was finally blocked by Diawara.

In the 19th minute of the game, Klason sent a through ball from the right side of the front court. Kleiber quickly advanced to the bottom and then passed the ball back to the triangle. Tadic pushed the goal from the center of the penalty area. The ball was shot because of the angle It was steadily confiscated by P. Lopez. In the 35th minute, Neres made a pass from the left in the front court, Tadic followed up with a foot pad shot in the middle, and P Lopez immediately took the ball into his arms. Since then, both sides have made no achievements, they entered the intermission with a score of 0-0.

Only 3 minutes after the two sides changed sides, Ajax broke through the goal of Rome with lightning speed. Scholes launched an offensive with a long pass from the backcourt. P. Lopez made a wrong decision at this time: he abandoned the goal and tried to save. He didn't want Brobe to face P. Lopez and shoot the empty goal. Ah Jax advanced a goal to break the deadlock on the field, and the two sides also returned to the same starting line because the total score was tied. In the 55th minute, Ajax attacked again after Rossi stole the ball from Mkhitaryan. Brobe’s long-range shot at the top of the arc was saved by P. Lopez, and Tadic followed up with a supplementary shot in front of the goal. The goal was scored; however, after a review by VAR, the referee stated that Rossi dropped Mkhitaryan for the first foul and the goal was declared invalid.

Although the two sides attacked each other, the score on the field remained unchanged; until the 71st minute, Calafioli broke into the left side of the penalty area with the ball and then crossed the ball. Dzeko outflanked the goal and pushed it in place. Shooting a close corner succeeded, Rome evened the score in one fell swoop. Since then, Roma and Ajax have not scored a chance to score again, and they finally ended the game with a 1-1 draw. However, Roma finally eliminated Ajax with a total score advantage, becoming the only Serie A team to enter the Europa League semi-finals.